منابع مشابه
Dynamic mechanical (brush) allodynia in cluster headache.
OBJECTIVE To examine the occurrence of dynamic mechanical (brush) allodynia (BA) in patients with cluster headache (CH). BACKGROUND Cutaneous allodynia was described in migraine. It was related to sensitization of neurons in the trigeminal nucleus caudalis (TNC). This phenomenon has not been previously described in cluster headache. METHODS We examined adult patients with episodic or chroni...
متن کاملLithium reverses mechanical allodynia through a mu opioid-dependent mechanism
Background Lithium is widely used to treat bipolar disorders and displays mood stabilizing properties. In addition, lithium relieves painful cluster headaches and has a strong analgesic effect in neuropathic pain rat models. Objectives To investigate the analgesic effect of lithium on the cuff model of neuropathic pain. Methods We used behavioral and pharmacological approaches to study the anal...
متن کاملA role for Piezo2 in EPAC1-dependent mechanical allodynia
Aberrant mechanosensation has an important role in different pain states. Here we show that Epac1 (cyclic AMP sensor) potentiation of Piezo2-mediated mechanotransduction contributes to mechanical allodynia. Dorsal root ganglia Epac1 mRNA levels increase during neuropathic pain, and nerve damage-induced allodynia is reduced in Epac1-/- mice. The Epac-selective cAMP analogue 8-pCPT sensitizes mec...
متن کاملDynamic Mechanical Allodynia in Peripheral Neuropathic Pain: Psychophysical Observations
All previously published papers were reproduced with permission from the publisher. ABSTRACT Introduction and aim: Pain due to a light moving mechanical stimulus, dynamic mechanical allodynia, is a protruding symptom/sign in subgroups of patients with peripheral neuropathic pain and frequently as troublesome as spontaneous ongoing pain. The objective of this thesis was to survey psychophysical ...
متن کاملUnravelling Spinal Circuits of Pain and Mechanical Allodynia
How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underl...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2014
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-014-1532-0